The basics
Sirolimus (brand name- Fyarro) is an FDA-approved treatment for epithelioid cell tumor (soft tissue cancer that can form in any part of the body) that has spread to nearby tissues or to other parts of the body or can not be removed by surgery.
Sirolimus falls in a class of kinase inhibitors medication. It works by blocking the action of the abnormal protein that tells the cancer cells to multiply. This may help slow the growth of tumors.
Let us walk you through the key things you need to know about sirolimus.
How should I take sirolimus (Fyarro)?
Sirolimus (with albumin) is slowly injected into a vein over 30 minutes by a doctor or nurse in a medical facility. Sirolimus (with albumin) injection is usually given on days 1 and 8 of a 21 day cycle.
Your doctor may need to interrupt your treatment, reduce your dose, or stop your treatment depending on your response to the medication and any side effects that you experience. Be sure to tell your doctor how you are feeling during your treatment.
Do not stop taking treatment without talking to your doctor. You can help them by tracking your side effects in Ankr.
What are the side effects of sirolimus (Fyarro)?
Common side effects
- nausea
- vomiting (emesis)
- diarrhea (loose stools)
- stomach pain
- constipation
- dry Mouth (xerostomia)
- hemorrhoids
- abnormal taste (dysgeusia)
- fatigue (tiredness)
- headache
- hair loss (alopecia)
- appetite loss (Anorexia)
- abnormal weight loss
- muscle, back, or neck pain
- insomnia
- sores in or around the mouth or lips
- fever, sore throat, chills, or other signs of infection
- cough
- hives
- rash
- itching
- hoarseness
Serious side effects
- shortness or breath or painful breathing
- pain or burning on urination, pain in lower back, or difficulty urinating
- unusual bleeding or bruising
- red or black, tarry stools
- coughing up or vomiting blood or brown material that looks like coffee grounds
- swollen, red, cracked, scaly skin
- difficulty breathing or swallowing
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
Sirolimus (with albumin) injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).
Use the free Ankr platform or Ankr app to track your symptoms.
What special precautions should I follow?
Before receiving sirolimus (Fyarro)
- tell your doctor about your allergies
- tell your doctor about other intakes
- tell your doctor if you have or have ever had any disease, symptom, or treatment
- tell your doctor if you are pregnant or plan to become pregnant.Talk to your doctor about birth control methods that will work for you.
While you are on sirolimus (Fyarro)
- If you become pregnant while receiving sirolimus (with albumin) injection, call your doctor. Sirolimus (with albumin) injection may harm the fetus.
- if you have diabetes, you should know that sirolimus (with albumin) injection may increase glucose levels. Your doctor may ask you to monitor your blood glucose more frequently during your treatment with (with albumin) injection.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving sirolimus (with albumin) injection.
- do not have any vaccinations without talking to your doctor.
What special dietary instructions should I follow?
Do not eat large amounts of grapefruit or drink grapefruit juice while receiving this medication.
Brand names
- Fyarro®
Last Revised – 06/23/2023, FDA updated- 04/15/2022, SG
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