How should I take 5-Fluorouracil (Adrucil)?

Fluorouracil injection comes as a solution (liquid) to be given into a vein by a doctor or nurse. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.

Your doctor may need to delay your treatment or change your dose if you experience certain side effects. You should tell your doctor how you feel during your fluorouracil injection treatment. You can help them by tracking your side effects in Ankr.

What are the side effects of 5-Fluorouracil (Adrucil)?

• loss of appetite
• nausea
• unusual tiredness or weakness
• dizziness
• headache
• hair loss
• dry and cracked skin
• vision changes
• eyes that are teary or sensitive to light
• redness, pain, swelling, or burning at the site where the injection was given
• confusion

Serious side effects

Take medical services immediately if you experience

• sores in the mouth and throat
• diarrhea
• vomiting
• swelling, pain, redness, or peeling of skin on the palms and soles of the feet
• fever, chills, sore throat, or other signs of an infection
• hives
• rash
• itching
• difficulty breathing or swallowing
• nosebleeds
• coughing up or vomiting blood or material that looks like coffee grounds
• unusual bleeding or bruising
• pink, red, or dark brown urine
• red or tarry black bowel movements
• chest pain

Fluorouracil may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms

What special precautions should I follow?

Before taking 5-Fluorouracil (Adrucil)

• tell your doctor about your allergies
• tell your doctor about other intakes
• also tell your doctor if you have an infection and about past or current diseases and their treatments.
• you should not become pregnant or breastfeed while you are receiving fluorouracil injections. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

While you are on 5-Fluorouracil (Adrucil)

• if you become pregnant while receiving fluorouracil injections, call your doctor. Fluorouracil may harm the fetus.
• you should avoid unnecessary or prolonged sunlight exposure and wear protective clothing, sunglasses, and sunscreen. Fluorouracil may make your skin sensitive to sunlight.

I forgot a dose. What should I do?

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• nausea
• diarrhea
• vomiting
• fever, chills, sore throat, or other signs of an infection
• unusual bleeding or bruising
• bloody or black, tarry stools
• coughing up or vomiting blood or material that looks like coffee grounds

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

• Adrucil^® 

This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 02/17/2023, SG