Margetuximab (Margenza)

Margetuximab-cmkb injection may cause serious or life-threatening heart problems. Tell your doctor if you have or have ever had heart disease. Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive margetuximab-cmkb injection.

Tell your doctor and pharmacist if you are being treated with anthracycline medications for cancer such as daunorubicin (Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), and idarubicin (Idamycin) or within 4 months after receiving margetuximab-cmkb injection.

If you experience any of the following symptoms, call your doctor immediately: cough; shortness of breath; swelling of the arms, hands, feet, ankles or lower legs; weight gain (more than 5 pounds [about 2.3 kilograms] in 24 hours); dizziness; loss of consciousness; or fast, irregular, or pounding heartbeat.

Margetuximab-cmkb injection should not be used by women who are pregnant or who may become pregnant. There is a risk that margetuximab-cmkb will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth). Tell your doctor if you are pregnant or plan to become pregnant. You will need to have a pregnancy test before you receive this medication. You should use effective birth control during treatment with margetuximab-cmkb and for 4 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant during treatment with margetuximab-cmkb injection, or think you might be pregnant, call your doctor immediately.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body’s response to margetuximab-cmkb.

Talk to your doctor about the risk(s) of receiving margetuximab-cmkb.

The basics

Margetuximab (brand name- Margenza) is an FDA-approved treatment used along with chemotherapy for breast cancer (HER-2 positive) that has spread to other parts of the body after treatment with at least two other chemotherapy medications.

Margetuximab (Margenza) is in a class of medications called monoclonal antibodies. It works by stopping the growth of cancer cells.

Let us walk you through the key things you need to know about Margetuximab.

How should I take margetuximab (Margenza)?

Patient getting IV chemotherapy

Margetuximab-cmkb comes as a solution to be injected into a vein by a doctor or nurse in a medical facility.

Tell your doctor or nurse if you experience any of the symptoms mentioned in next section during your infusion. Your doctor may slow down your infusion or temporarily or permanently stop your treatment.. Be sure to tell your doctor how you are feeling during your treatment with margetuximab-cmkb injection.

Do not stop taking treatment without talking to your doctor. You can help them by tracking your side effects in Ankr.

What are the side effects of margetuximab (Margenza)?

Common side effects

Serious side effects

Margetuximab-cmkb may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before receiving margetuximab-cmkb injection

  • tell your doctor about your allergies
  • tell your doctor about other intakes
  • tell your doctor if you have or have ever had any disease, treatment, or symptom

While you are on margetuximab-cmkb injection

  • if you or your partner becomes pregnant while taking cisplatin, call your doctor immediately. Cisplatin may harm the fetus.
  • tell your doctor if you are breastfeeding. You should not breastfeed during your treatment with margetuximab-cmkb and for four months after your final dose.

I forgot a dose. What should I do?

Call your doctor right away if you are unable to keep an appointment to receive a dose of margetuximab-cmkb injection.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

  • Margenza®

Last Revised – 06/10/2023, FDA updated-02/15/2021, SG

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DISCLAIMER: No part of this content constitutes medical advice, opinion, or should be used for medical decision making without consultation with a licenced medical practitioner and under a patient-provider relationship. All information on the website is provided without any claims of accuracy. For full terms and conditions, visit this link. Content curated by the Ankr team.

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