Dostarlimab (Jemperli)

The basics

Dostarlimab-gxly (brand name- Jemperli) injection is an FDA-approved treatment for endometrial cancer (cancer that begins in the lining of the uterus) in adults that have progressed or have returned after treatment with other chemotherapy medication(s).

Dostarlimab-gxly injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain protein in cancer cells. This helps the person’s immune system to fight against the cancer cells and helps to slow tumor growth.

Let us walk you through the key things you need to know about dostarlimab.

How should I take dostarlimab (Jemperli)?

Patient getting IV chemotherapy

Dostarlimab-gxly injection comes as a solution (liquid) to inject into a vein over 30 minutes by a doctor or nurse in a medical facility. Dostarlimab-gxly injection may cause serious or life-threatening reactions during an infusion.

A doctor or nurse will watch you closely while you are receiving the infusion to be sure you are not having a serious reaction to the medication. Tell your doctor or nurse immediately if you experience any of the following symptoms that may occur during the infusion: chills, flushing, shaking, dizziness, shortness of breath, wheezing, fever, itching, rash, back or neck pain, or feeling faint.

Talk to your doctor about how you are feeling during your treatment. You can help them by tracking your side effects in Ankr.

What are the side effects of dostarlimab or Jemperli?

Common side effects

Serious side effects

  • Chest pain, or shortness of breath (dyspnea)
  • Black, tarry, sticky stools, or stools that have blood or mucus in them
  • Stomach-area pain or tenderness
  • Dark-colored urine
  • Bleeding or bruising more easily than normal
  • Headaches, including those that are unusual or will not go away
  • Changes in mood or behavior (decreased sex drive, irritability, or forgetfulness)
  • Dizziness or fainting
  • Vision changes
  • Fast heartbeats
  • Change in amount or color of urine; blood in the urine; or loss of appetite
  • Pale skin or shortness of breath
  • Swollen lymph nodes
  • Delirium (Confusion)
  • Balance problems
  • stiff neck, memory problems, or seizures
  • Hallucinations (seeing things or hearing voices that do not exist)

Dostarlimab-gxly may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before receiving dostarlimab-gxly injection

  • tell your doctor about your allergies
  • tell your doctor about other intakes
  • tell your doctor if you have or ever had any other disease or symptom
  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are receiving dostarlimab-gxly injection and for at least four months after your final dose

While you are on dostarlimab-gxly injection

  • If you become pregnant while receiving dostarlimab-gxly injection, call your doctor immediately. Dostarlimab-gxly injection may harm the fetus.
  • Tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while receiving dostarlimab-gxly injection and for four months after your final dose.

I forgot a dose. What should I do?

If you miss an appointment to receive dostarlimab-gxly injection, call your doctor as soon as possible.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

  • Jemperli®

Last Revised, 06/10/2023, FDA updated – 10/15/2021, SG

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