How Should I take enzalutamide (Xtandi)?

Enzalutamide comes as a capsule to be taken through the mouth with or without food. Take your prescribed dose one time a day, at the same time each day. Swallow the capsules whole. Do not chew, dissolve, or open the capsules.

If you are receiving gonadotropin-releasing hormone (GnRH) therapy, you should continue with this treatment during your treatment with Xtandi unless you have had surgery to lower the amount of testosterone in your body (surgical castration).

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take the capsule exactly as directed. Do not take more or less of it or more often than your doctor prescribes.

Do not stop taking Enzalutamide without talking to your doctor. You can help them by tracking your side effects in Ankr.

What are the Side effects of enzalutamide (Xtandi)?

Enzalutamide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before taking enzalutamide

• tell your doctor about your allergies.
• tell your doctor about other intakes.
• tell your doctor if you have taken chlorambucil before, but your cancer did not respond to the medication.
• tell your doctor if you have or ever had any other disease or symptom.

While you are on enzalutamide

• If you or your partner becomes pregnant while taking enzalutamide, call your doctor immediately. Chlorambucil may harm the fetus.
• Tell your doctor if you are breastfeeding. You should not breastfeed during your treatment with enzalutamide
• Do not have any vaccinations without talking to your doctor.

I forgot a dose. What should I do?

If you miss a dose of enzalutamide, take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose each day.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• seizure
• Loss of consciousness

How should I safely store and dispose of enzalutamide (Xtandi)

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it in the refrigerator.

To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

You should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you cannot access a take-back program.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

• Enzamide
• Glenza
• Samluta
• Xtandi
• Xylutide

Last revised:06/14/2023, Last updated: 12/04/2019, SG