Relugolix (Orgovyx)

The basics

Relugolix (brand name-Orgovyx) is an FDA-approved treatment for advanced prostate cancer (cancer that begins in the prostate [a male reproductive gland]) in adults.

Relugolix is in a class of medications called gonadotropin-releasing hormone (GnRH) receptor antagonists. It works by decreasing the amount of testosterone (a male hormone) produced by the body. This may slow or stop the spread of prostate cancer cells that need testosterone to grow.

Let us walk you through the key things you need to know about relugolix.

How should I take relugolix (Orgovyx)?

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Relugolix comes as a tablet to take by mouth. It is usually taken with or without food once daily. Take relugolix at around the same time every day. Follow the directions on your prescription label carefully. Take relugolix exactly as directed.

Do not take more or less of it or take it more often than prescribed by your doctor.Swallow the tablets whole; do not split, chew, or crush them.

Do not stop taking relugolix without talking to your doctor. You can help them by tracking your side effects in Ankr.

What are the side effects of relugolix (Orgovyx)?

Common side effects

Serious side effects

  • Dizziness
  • Fainting
  • heart racing
  • Chest Pain or pressure; or pain in arms, back, neck, or jaw
  • Sudden numbness or weakness of face, arm, or leg (especially on one side of the body);
  • Sudden confusion
  • Trouble speaking or understanding
  • Sudden trouble seeing in one or both eyes
  • Sudden trouble walking
  • Loss of balance or coordination

Relugolix may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before taking relugolix (Orgovyx)

  • tell your doctor about your allergies
  • tell your doctor about other intakes
  • tell your doctor if you have or have ever had any disease, symptom, or treatment
  • you should know that relugolix is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breast-feeding.

While you are on relugolix (Orgovyx)

  • If you are a male and your female partner can become pregnant, you should use effective contraception during treatment and for 2 weeks after the last dose. Relugolix may harm the fetus.
  • you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of taking relugolix.

I forgot a dose. What should I do?

If you miss a dose by less than 12 hours, take the missed dose as soon as you remember it and then take the next dose at the scheduled time. However, if you miss a dose by more than 12 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you miss more than 7 days of treatment, talk to your doctor before starting to take it again. You will probably have to restart taking it at a higher dose initially.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

How should I safely store and dispose of relugolix (Orgovyx)?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant (small packet included with medication to absorb moisture).

To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

You should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

  • Orgovyx®

Last Revised – 06/22/2023, FDA updated- 02/15/2021, SG

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DISCLAIMER: No part of this content constitutes medical advice, opinion, or should be used for medical decision making without consultation with a licenced medical practitioner and under a patient-provider relationship. All information on the website is provided without any claims of accuracy. For full terms and conditions, visit this link. Content curated by the Ankr team.

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