How should I take Talazoparib (Talzenna)?

Talazoparib comes as a capsule to take by mouth. It is usually taken with or without food once a day. Take talazoparib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take talazoparib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not dissolve or open them. If you vomit after taking talazoparib, do not take another dose. Continue your regular dosing schedule.

Be sure to tell your doctor how you are feeling during your treatment with talazoparib. You can help them by tracking your side effects in Ankr.

What are the side effects of Talazoparib (Talzenna)?

Talazoparib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before taking talazoparib (Talzenna)

• tell your doctor about your allergies
• tell your doctor about other intakes
• tell your doctor if you have or have ever had any disease, symptom, or treatment
• tell your doctor if you are pregnant, plan to become pregnant, or if you plan to father a child. Talk to your doctor about birth control methods that you can use during your treatment.

While you are on talazoparib (Talzenna)

• if you or your partner become pregnant while taking talazoparib, call your doctor. Talazoparib may harm the fetus.
• tell your doctor if you are breastfeeding. You should not breastfeed while you are taking talazoparib and for 1 month after your final dose.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking talazoparib.

I forgot a dose. What should I do?

If you miss a dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

How should I safely store and dispose of Talazoparib (Talzenna)

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

You should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

• Talzenna^®

Last Revised -06/24/2023, FDA-updated- 09/04/2023, SG