Sotorasib (Lumakras)

The basics

Sotorasib (brand name-Lumakras) is an FDA-approved treatment for lung cancer (non-small cell lung cancer; NSCLC) that has spread to other parts of the body or cannot be removed by surgery in adults who have received at least one other treatment.

Sotorasib is in a class of medications called KRAS inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

Let us walk you through key things you need to know about sotorasib.

How should I take sotorasib (Lumakras)?

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Sotorasib comes as a tablet to take by mouth. It is usually taken once daily with or without food. Take sotorasib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sotorasib exactly as directed.

Swallow the tablets whole; do not split, chew, or crush them. If you vomit after taking sotorasib, do not take another dose. Continue your regular dosing schedule the next day. Continue to take sotorasib even if you feel well. Do not stop taking sotorasib without talking to your doctor.

Do not stop taking Sotorasib without talking to your doctor. You can help them by tracking your side effects in Ankr.

What are the side effects of sotorasib (Lumakras)?

Sotorasib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before taking sotorasib (Lumakras)

  • tell your doctor about your allergies
  • tell your doctor about other intakes
  • tell your doctor if you have or have ever had any other disease, symptom, or treatment

While you are on sotorasib (Lumakras)

  • tell your doctor if you are pregnant, or plan to become pregnant. If you become pregnant while taking sotorasib, call your doctor immediately.
  • tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while receiving sotorasib and for 1 week after your final dose.

I forgot a dose. What should I do?

Take the missed dose as soon as you remember it. However, if it has been more than 6 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

How should I safely store and dispose of sotorasib (Lumakras)?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of sight and reach.

You should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

  • Lumakras®

Last Revised –  12/26/2023, FDA-updated-010/12/2023,SG

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DISCLAIMER: No part of this content constitutes medical advice, opinion, or should be used for medical decision making without consultation with a licenced medical practitioner and under a patient-provider relationship. All information on the website is provided without any claims of accuracy. For full terms and conditions, visit this link. Content curated by the Ankr team.

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