Rucaparib (Rubraca)

The basics

Rucaparib (brand name-Rubraca) is an FDA-approved treatment for ovarian, fallopian tube, and primary peritoneal (layer of tissue that lines the abdomen) cancers and metastatic prostate cancer that carriers certain gene (BRCA1/2) mutations.

It is in a class of medications called poly (ADP-ribose) polymerase (PARP) inhibitors. It works by killing cancer cells.

Let us walk you through the key things you need to know about rucaparib.

How should I take rucaparib (Rubraca)?

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Rucaparib comes as a tablet to take by mouth. It is usually taken with or without food twice daily, about 12 hours apart. Take rucaparib at around the same times every day. Take rucaparib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Talk to your doctor about how you are feeling during your treatment. Do not stop taking rucaparib without talking to your doctor. If you vomit after taking rucaparib, do not take another dose. Continue your regular dosing schedule.

Do not stop taking rucaparib without talking to your doctor. You can help them by tracking your side effects in Ankr.

What are the side effects of rucaparib (Rubraca)?

Serious side effects

Rucaparib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before taking rucaparib (Rubraca)

  • tell your doctor about your allergies
  • tell your doctor about other inatkes
  • tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You should not become pregnant while you are taking rucaparib. Talk to your doctor about birth control methods that will work for you.

While you are on rucaparib (Rubraca)

  • If you become pregnant while taking rucaparib, call your doctor.
  • tell your doctor if you plan to breastfeed. You should not breastfeed during your treatment with rucaparib and for 2 weeks after your final dose.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, a hat, sunglasses, and sunscreen. Rucaparib may make your skin sensitive to sunlight.

I forgot a dose. What should I do?

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

How should I safely store and dispose of rucaparib?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

You should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

  • Rubraca®

Last Revised -06/24/2023, FDA updated- 07/19/2022, SG

[ref: 07/15/2020]

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DISCLAIMER: No part of this content constitutes medical advice, opinion, or should be used for medical decision making without consultation with a licenced medical practitioner and under a patient-provider relationship. All information on the website is provided without any claims of accuracy. For full terms and conditions, visit this link. Content curated by the Ankr team.

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