Opdualag (nivolumab + relatlimab)

The basics

Opdualag (nivolumab + relatlimab) is an FDA-approved treatment for melanoma (a type of skin cancer) that has spread to other body parts or cannot be removed by surgery. It is approved for use in adults and children 12 years of age or older who weigh at least 40 kg.

Opdualag is in a class of medications called immunotherapy. They work by activating your immune system to find and kill cancer cells.

let us walk you through the key things you need to know about opdualag.

How should I take Opdualag (nivolumab + relatlimab) ?

Patient getting Opdualag cancer treatment

Opdualag is given as an infusion into a vein over 30 minutes by a doctor or nurse in a hospital or medical facility. It is usually given every 4 weeks for as long as your doctor recommends that you receive treatment.

Opdualag can cause serious or life-threatening reactions during an infusion.Tell your doctor or nurse immediately if you experience any of the following symptoms that may occur during the infusion: chills or shaking, itching, rash, flushing, difficulty breathing, dizziness, fever, and feeling faint.

Do not stop taking treatment without talking to your Doctor. You can help them by tracking your side effects in Ankr.

What are the side effects of Opdualag (nivolumab + relatlimab)?

Common side effects

  • diarrhea (Loose stools)
  • stools that are black, tarry, sticky, or contain blood
  • tiredness or weakness
  • feeling cold
  • deepening of voice or hoarseness
  • increased sweating
  • changes in weight (gain or loss)
  • pain, burning, tingling, or numbness in the hands or feet
  • headaches, including those that are unusual or will not go away
  • fever
  • hair loss (alopecia)
  • itching, rash, hives, or blisters on your skin
  • constipation
  • nausea
  • vomiting (emesis)
  • drowsiness
  • yellowing of skin or eyes, loss of appetite, decreased energy, or pain on the right side of stomach area
  • increased thirst
  • decreased or increased urination
  • swelling of face, arms, legs, feet or ankles
  • changes in vision, including sensitivity to light
  • breath that smells fruity

Serious side effects

  • changes in mood or behavior (decreased sex drive, irritability, or forgetfulness)
  • rapid heartbeat
  • shortness of breath (Dyspnea)
  • new or worsening cough
  • coughing up blood
  • chest Pain
  • blood in urine
  • dizziness or fainting
  • dark-colored urine, bleeding or bruising more easily than normal
  • confusion
  • painful sores in mouth, nose, throat, or genital area
  • stomach area pain or tenderness

Nivolumab and relatlimab may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before taking Opdualag (nivolumab + relatlimab)

  • tell your doctor about your allergies
  • tell your doctor about other intakes
  • tell your doctor if you have or have ever had any disease, symptom, or treatment
  • tell your doctor if you are pregnant or plan to become pregnant.

While you are on Opdualag (nivolumab + relatlimab)

  • if you become pregnant while receiving Opdualag, call your doctor immediately as it may harm the fetus.
  • tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while receiving Opdualag and for 5 months after your final dose.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

  • Opdualag®

Last Revised -06/19/2023, FDA uodated- 05/15/2022, SG

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DISCLAIMER: No part of this content constitutes medical advice, opinion, or should be used for medical decision making without consultation with a licenced medical practitioner and under a patient-provider relationship. All information on the website is provided without any claims of accuracy. For full terms and conditions, visit this link. Content curated by the Ankr team.

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