Mobocertinib (Exkivity)

Mobocertinib may cause QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death). Tell your doctor if you or anyone in your family has or has ever had long QT syndrome (an inherited condition in which a person is more likely to have QT prolongation) or you have or have ever had low levels of potassium or magnesium in your blood, an irregular heartbeat, or heart failure. Tell your doctor and pharmacist if you are taking any of the following medications: amiodarone (Nexterone, Pacerone); azithromycin (Zithromax); ciprofloxacin (Cipro); clarithromycin; disopyramide (Norpace); dofetilide (Tikosyn); dronedarone (Multaq); erythromycin (E.E.S., Eryc, Ery-tab, Erythrocin); fluconazole (Diflucan); certain medications for HIV such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); haloperidol (Haldol); ibutilide (Corvert); itraconazole (Sporanox, Tolsura); ketoconazole; levofloxacin; moxifloxacin; ondansetron (Zofran); procainamide; quinidine (in Nuedexta); sotalol (Betapace, Sorine, Sotylize); or voriconazole (Vfend). If you experience any of the following symptoms, call your doctor immediately: fast, pounding, or irregular heartbeat; dizziness; lightheadedness; or fainting.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, such as blood tests and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take mobocertinib.

Talk to your doctor about the risks of taking mobocertinib.

The basics

Mobocertinib (brand name-Exkivity) is an FDA-approved treatment for non-small cell lung cancer (NSCLC) that can not be removed by surgery. It is used to treat cancer that has spread to other parts of the body either during or after treatment with platinum chemotherapy medications.

Mobocertinib (exkivity) falls in a class of kinase inhibitors medications. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells and may help shrink tumors.

Let us walk you through the key things you need to know about Mobocertinib.

How should I take mobocertinib (Exkivity)?

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Mobocertinib (exkivity) comes as a capsule to take by mouth once daily with or without food. Take mobocertinib at around the same time every day. Take mobocertinib exactly as directed. Do not take more or less of it or more often than your doctor prescribes.

Swallow the capsules whole; do not open, chew, crush, or dissolve them. If you vomit after taking mobocertinib (exkivity), do not take another dose. Continue your regular dosing schedule.

Talk to your doctor about how you are feeling during your treatment. Do not stop taking mobocertinib without talking to your doctor. You can help them by tracking your side effects in Ankr.

You can also visit the Food and Drug Administration (FDA) website to obtain the Medication Guide

What are the side effects of mobocertinib (Exkivity)?

Mobocertinib (exkivity) may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms

What special precautions should I follow?

Before taking mobocertinib or Exkivity

  • tell your doctor about your allergies
  • tell your doctor about other intakes
  • tell your doctor if you have or have ever had any other disease, symptom, or treatment
  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. Talk to your doctor about birth control method you should use.

While you are on mobocertinib or Exkivity

  • If you or your partner become pregnant while taking mobocertinib, call your doctor immediately. Mobocertinib may harm the fetus.
  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking mobocertinib.
  • you should know that mobocertinib often causes diarrhea, which can be severe.

I forgot a dose. What should I do ?

If you miss a dose by less than 6 hours, take the missed dose as soon as you remember it and then take the next dose at the scheduled time. However, if you miss a dose by more than 6 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

How should I safely store and dispose of mobocertinib?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

You can dispose of unneeded medications in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Brand names

  • Exkivity®

Last Revised – 06/18/2023, FDA-updated- 09/15/2021, SG

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DISCLAIMER: No part of this content constitutes medical advice, opinion, or should be used for medical decision making without consultation with a licenced medical practitioner and under a patient-provider relationship. All information on the website is provided without any claims of accuracy. For full terms and conditions, visit this link. Content curated by the Ankr team.

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