Hand-Foot Syndrome

What is hand foot syndrome?
Hand Foot Syndrome

Hand-foot syndrome is characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet. It is also known as Palmar-plantar erythrodysesthesia syndrome. The syndrome is a side effect of cancer treatments. It causes redness, blisters, swelling, and pain on the palms of the hands and/or the soles of the feet. Hand-foot syndrome sometimes happens on the knees or elbows.

It is a skin reaction that occurs when a small amount of the medication leaks out of capillaries (small blood vessels), usually on the palms of the hands and soles of the feet. When the medication leaks out of the capillaries, it can damage the surrounding tissues. The hand-foot syndrome can be painful and can affect your daily living.

How bad is my hand foot syndrome?

Mild: Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain.

Moderate: Skin changes (e.g., peeling, blisters, bleeding, fissures, edema, or hyperkeratosis) with pain; limiting
instrumental activities of daily life.

Severe: Severe skin changes (e.g., peeling, blisters, bleeding, fissures, edema, or hyperkeratosis) with pain; limiting self-care activities of daily life.

How to manage mild hand foot syndrome?

It is worse during the first 6 weeks of treatment with targeted therapy. With chemotherapy, it appears after 2 to 3 months.

The following tips may help:

  • Limit the use of hot water when bathing.
  • Take cool showers or baths. Carefully pat dry skin after washing or bathing.
  • Cool your hands and feet. Use ice packs, cool running water, or a wet towel for 15 to 20 minutes at a time. Never apply ice directly to the skin.
  • Avoid sources of heat (saunas, sitting in the sun, or sitting in front of a sunny window).
  • Restrict activities (jogging, aerobics, and racquet sports.) that cause force or rubbing on the hands or feet during the first 6 weeks of treatment.
  • Avoid contact with harsh chemicals used in laundry detergents or household cleaning products.
  • Never use tools or household items (garden tools, knives, and screwdrivers) that require you to press your hand against a hard surface.
  • Avoid rubbing or massaging lotion into your hands and feet.
  • Wear loose fitting, well-ventilated shoes and clothes.
  • Use soft slippers and thick socks to reduce friction on your feet.
How to manage moderate and severe hand foot syndrome?

If you notice early signs or if you notice your symptoms worsening, call your doctor’s office. Your health care team may need to change your treatment or help you manage the symptom.

What are the causes?

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