Enfortumab (Padcev)

The basics

Enfortumab (brand name-Padcev) is an FDA-approved treatment for urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract) that has spread to nearby tissues or other parts of the body and has worsened after treatment with other chemotherapy medications.

Enfortumab vedotin-ejfv injection is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.

Let us walk you through the key things you need to know about enfortumab

How should I take enfortumab (Padcev)?

Enfortumab vedotin-ejfv is injected into a vein over 30 minutes by a doctor or nurse in a medical facility. It is usually injected on days 1, 8, and 15 of a 28-day cycle for as long as your doctor recommends that you receive treatment.

Patient getting IV chemotherapy

Your doctor may delay or stop your treatment with enfortumab vedotin-ejfv injection, or treat you with additional medications, depending on your response to the medication and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.

Do not stop taking treatment without talking to your doctor. You can help them by tracking your side effects in Ankr.

What are the side effects of enfortumab (Padcev)?

Common side effects

Serious side effects

  • shortness of breath
  • skin redness, swelling, fever, or pain at injection site
  • blurred vision, loss of vision, eye pain or redness, or other visual changes
  • numbness, burning, or tingling in hands or feet
  • muscle weakness
  • extreme tiredness or lack of energy

Enfortumab vedotin-ejfv injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before receiving enfortumab (Padcev)

  • tell your doctor about your allergies
  • tell your doctor about other intakes
  • tell your doctor if you have or have ever had medical condition or treatment
  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan to father a child. Talk to your doctor about birth control methods that will work for you.

While you are on enfortumab (Padcev)

  • If you or your partner become pregnant while receiving enfortumab vedotin-ejfv injection, call your doctor. Enfortumab vedotin-ejfv injection may harm the fetus.
  • tell your doctor if you are breast-feeding. You should not breast-feed while you are receiving enfortumab vedotin-ejfv injection and for at least 3 weeks after your final dose.
  • you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of receiving enfortumab vedotin-ejfv injection.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

Brand names

  • Padcev®

Last Revised – 06/30/2023, FDA updated-02/15/2020, SG

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DISCLAIMER: No part of this content constitutes medical advice, opinion, or should be used for medical decision making without consultation with a licenced medical practitioner and under a patient-provider relationship. All information on the website is provided without any claims of accuracy. For full terms and conditions, visit this link. Content curated by the Ankr team.

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