Sacituzumab govitecan-hziy (brand name- Trodelvy) is an FDA-approved treatment for breast cancer in adults that has spread to other parts of the body or cannot be removed by surgery and who have already been treated with at least two other chemotherapy medications.
Sacituzumab govitecan-hziy is in a class of medications called antibody-drug conjugates. It works by killing cancer cells.
Let us walk you through the key things you need to know about Sacituzumab govitecan-hziy
Make sure you read the IMPORTANT WARNING at the end of this article.
How should I take sacituzumab govitecan-hziy (Trodelvy)?
Sacituzumab govitecan-hziy is injected into a vein over 1 to 3 hours by a doctor or nurse in a medical facility. Sacituzumab govitecan-hziy injection may cause nausea, vomiting, and serious allergic reactions, which usually occur during the infusion of the medication or within 24 hours of receiving a dose.
Be sure to tell your doctor how you are feeling during your treatment with sacituzumab govitecan-hziy.
Do not stop taking treatment without talking to your doctor. You can help them by tracking your side effects in Ankr.
What are the side effects of sacituzumab govitecan-hziy (Trodelvy)?
Common side effects
- abdominal pain (bellyache)
- fatigue (tiredness)
- appetite loss (anorexia)
- abnormal taste (dysgeusia)
- hair loss (alopecia)
- dry skin
- pain, burning, or tingling in the hands or feet
- back or joint pain
- pain in arms or legs
- swelling of the hands, ankles, or feet
- swelling of your face, lips, tongue, or throat
Serious side effects
- difficulty breathing
- pale skin or unusual tiredness or weakness
- dizziness (vertigo)
- swelling around the mouth, face, eyes, stomach, feet, ankles, or lower legs
- sudden weight gain
- chest pain
- fast or irregular heartbeat
- fainting (syncope)
- unusual bruising or purple markings under the skin
- unusual bleeding
Sacituzumab govitecan-hziy may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).
What special precautions should I follow?
Before receiving sacituzumab govitecan-hziy (Trodelvy)
- tell your doctor about your allergies
- tell your doctor about other intakes
- tell your doctor if you have or have ever had any disease, symptom, or treatment
- tell your doctor if you are pregnant, plan to become pregnant, or if you plan to father a child. Talk to your doctor about birth control methods that will work for you.
While you are on sacituzumab govitecan-hziy (Trodelvy)
- If you or your partner becomes pregnant while receiving sacituzumab govitecan-hziy injection, call your doctor. Sacituzumab govitecan-hziy may harm the fetus.
- tell your doctor if you are breastfeeding. You should not breastfeed while you are receiving sacituzumab govitecan-hziy and for 1 month after your final dose.
I forgot a dose. What should I do?
If you miss an appointment to receive sacituzumab govitecan-hziy, call your doctor right away.
In case of an emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.
Symptoms of overdose may include
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
Last Revised – 06/23/2023, FDA-updated-07/15/2021, SG
Sacituzumab govitecan-hziy can cause severe or life-threatening decrease in the number of white blood cells in your blood. Your doctor will order laboratory tests regularly during your treatment to check the number of white blood cells in your blood. A decrease in the number of white blood cells in your body may increase the risk that you will develop a serious infection. If you experience any of the following symptoms, call your doctor immediately: fever, chills, sore throat, shortness of breath, ongoing cough, congestion, burning or pain when you urinate, or other signs of infection.
Sacituzumab govitecan-hziy can cause severe diarrhea. If you experience any of the following symptoms, call your doctor immediately: loose stools; diarrhea; black or bloody stools; signs of dehydration such as lightheadedness, dizziness, or faintness; or if you are unable to take fluids by mouth due to nausea or vomiting. Talk to your doctor about what you should do if you develop diarrhea at any time during your treatment with sacituzumab govitecan-hziy or if it is not controlled within 24 hours after treatment with medications for diarrhea.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body’s response to sacituzumab govitecan-hziy.
Talk to your doctor about the risks of receiving sacituzumab govitecan-hziy.
Get 24×7 support for sacituzumab govitecan-hziy (Trodelvy)
Don’t go through your cancer journey alone. Use Ankr to:
(1) find the best treatment for your cancer, and
(2) get advanced warning to cut side effects by upto 52%
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