How should I take tazemetostat (Tazverik)?

Tazemetostat (Tazverik) comes as a tablet to take by mouth. It is usually taken twice a day with or without food. Take tazemetostat at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tazemetostat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them. If you vomit soon after taking tazemetostat, do not take another dose. Continue your regular dosing schedule.

Be sure to talk to your doctor about how you are feeling during your treatment. Do not stop taking tazemetostat without talking to your doctor. You can help them by tracking your side effects in Ankr.

What are the side effects of tazemetostat (Tazverick)?

Tazemetostat (Tazverik) may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).

Use the free Ankr platform or Ankr app to track your symptoms.

What special precautions should I follow?

Before taking tazemetostat (Tazverick)

• tell your doctor about your allergies
• tell your doctor about other intakes
• tell your doctor if you have or have ever had other disease, symptoms, or treatment
• tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. Ask your doctor to help you choose a method of birth control that will work for you or your partner.

While you are on tazemetostat (Tazverick)

• If you or your partner become pregnant while taking tazemetostat, call your doctor immediately. Tazemetostat may harm the fetus.
• tell your doctor if you are breastfeeding. You should not breastfeed during your treatment and for 1 week after your final dose.

I forgot a dose. What should I do?

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

In case of an emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

How should I safely store and dispose of tazemetostat (Tazverick)?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

You should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Do not eat large amounts of grapefruit or drink grapefruit juice while taking this medication.

Brand names

• Tazverik^®

Last Revised -12/26/2023, FDA updated- 11/01/2023, SG