Amivantamab-vmjw (brand name- Rybrevant) is an FDA-approved treatment for non-small cell lung cancer (NSCLC). It is used for cancer that has spread to other body parts.
Amivantamab-vmjw injection belongs to the bispecific antibodies class of medications. It works by helping your immune system slow or stop cancer cell growth.
How should I take Amivantamab-vmjw (Rybrevant)?
Amivantamab-vmjw comes as a solution (liquid) to be injected slowly into a vein by a doctor or nurse in a medical facility. Talk to your doctor to decide the dose and length of treatment.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or more often than your doctor prescribes.
Your doctor may need to slow down your infusion or interrupt or stop your treatment if you experience certain side effects, such as nausea, shortness of breath, fever, chills, flushing, chest pain, lightheadedness, or vomiting. You can help them by tracking your side effects in Ankr.
What are the side effects of Amivantamab-vmjw or Rybrevant?
Common side effects
- Swelling, pain, or changes in the fingernails or toenails
- Unusual tiredness or weakness
- Swelling of the face, lips, or eyes
- Swelling of hands, feet, ankles, or lower legs
- Bone, muscle, arm, leg, neck, or back pain
- Joint pain
- Mouth sores
- Vomiting (Emesis)
- Diarrhea (Loose stools)
- Easy bruising or bleeding
- Blurred vision
- Abdominal Pain (Bellyache)
- Appetite loss (Anorexia)
- Numbness, tingling, pain, or burning in arms or legs
Serious side effects
- New or worsening cough
- Shortness of breath
- chest pain
- Eye pain
- Dry, red, teary, or itchy eyes
- Vision changes
- Sensitivity of eyes to light
- Bleeding gums or nose
- Blood in urine or stool
- Coughing up blood
- Dizziness (Vertigo)
Amivantamab-vmjw may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone (1-800-332-1088).
Use the free Ankr platform or Ankr app to track your symptoms.
What special precautions should I follow?
Before receiving amivantamab-vmjw or Rybrevant
- tell your doctor about your allergies
- tell your doctor about other intakes
- tell your doctor if you have or have ever had a lung disease other than lung cancer, or breathing problems.
While you are on amivantamab-vmjw or Rybrevant
- tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are receiving amivantamab-vmjw injection. Talk to your doctor about the types of birth control that are right for you. Amivantamab-vmjw injection may harm the fetus.
- tell your doctor if you are breastfeeding. You should not breastfeed amivantamab-vmjw or Rybrevant.
- you should know that amivantamab-vmjw may cause severe skin reactions. You should plan to avoid unnecessary or prolonged exposure to sunlight and wear protective clothing, sunglasses, and sunscreen. Your doctor may tell you to use an alcohol-free moisturizer if you develop dry or irritated skin.
I forgot a dose. What should I do?
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
In case of an emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
Last Revised – 03/01/2023, FDA update- 05/21/2021, SG
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